Replication timing networks reveal a link between transcription regulatory circuits and replication timing control

Replication Timing Networks: a novel class of gene regulatory networks

SnapShot: Replication Timing

Rif1 choreographs DNA replication timing.

Eukaryotic cells duplicate their genome in a predetermined order that appears to reflect a fundamental property of chromatin. Each chromosomal region replicates at a consistent, developmentaland tissue-specific time during the S phase of the cell cycle, and regions that replicate at the same time form distinct patterns in threedimensional nuclear space. Although orderly progression of DNA repli...

Control of Replication Timing by a Transcriptional Silencer

BACKGROUND Eukaryotic DNA replication starts at many origins. Some origins are used early in S phase, while others are programmed to fire later. In general, late replication is correlated with transcriptional inactivity and with location near the nuclear periphery. However, the mechanisms that determine replication timing are unclear, and the cause-and-effect relationship between late replicati...

Telomere-binding proteins play roles in control of replication timing

Comment on: Tazumi A, et al. Genes Dev 2012; 26:2050-62.